What is PRISTIQ?

PRISTIQ® (desvenlafaxine) is FDA approved to treat depression. It has been prescribed to 2.5 million patients since 2008.* In clinical studies, PRISTIQ 50 mg also helped improve patients’ ability to function according to a scale used to measure how depression disrupts the following areas:

  • Work
  • Social life/leisure activities
  • Family life/home responsibilities

Clinical studies of PRISTIQ 50 mg have also shown:

  • No significant difference in average weight gain versus placebo
  • A low occurrence of sexual side effects in men and women taking PRISTIQ, similar to those who took a placebo

*IMS Health Data, October 2016. Total prescriptions filled year-to-date October 2016; includes data for 50-mg and 100-mg tablets.

Sheehan Disability Scale (a validated measure of functional impairment) total score for PRISTIQ vs placebo.

Side effects may increase at higher doses. Data based on short-term studies and a 6-month phase of a long-term study of patients who responded to PRISTIQ. Individual results may vary.

How PRISTIQ works

Depression is a serious medical condition that can hold you back from what you enjoy. And while no one knows for certain what causes it, experts believe that depression results when certain chemicals in the brain are out of balance. These chemicals, called neurotransmitters, relay messages from one brain cell to another.

PRISTIQ is in a class of medications known as SNRIs, or serotonin-norepinephrine reuptake inhibitors. Serotonin and norepinephrine are chemicals that relay messages from one brain cell to another.

PRISTIQ is thought to work by affecting the levels of these two brain chemicals, both thought to play a role in depression.

Common side effects

While the goal of taking PRISTIQ is to feel better, it’s important to know that everyone responds differently to medication. And when it comes to antidepressants, there are side effects. Many people shy away from antidepressants due to side effects. It can take time to find the right medication for you.

You and your doctor can determine if the benefits of treatment outweigh the burden of side effects. Always discuss any side effects you are experiencing with your doctor.

In clinical studies, the most common side effects with PRISTIQ 50 mg were:

  • Nausea
  • Dizziness
  • Sweating
  • Constipation
  • Decreased appetite
  • Nausea
  • Dizziness
  • Sweating
  • Constipation
  • Decreased appetite

These are not all the possible side effects of PRISTIQ. For a complete list of side effects, please see the full Prescribing Information.

For additional information about PRISTIQ, review some answers to common questions.

Questions about Pristiq® (desvenlafaxine)Considering PRISTIQ: questions to ask your doctor

If you are still experiencing symptoms of depression, you may want to talk to your doctor about your treatment options. Here are some questions to help you start the conversation. You can print these questions out to take with you to your next doctor’s appointment.

If you are currently taking an antidepressant:

  • How do I know if my current medication is working?
  • Is an antidepressant right for me?
  • Should I try a different antidepressant?
  • Are there different types of antidepressants? Is there a different type that may work better for me?
  • Is PRISTIQ right for me?

If you are not taking an antidepressant right now:

  • Will my depression symptoms go away on their own?
  • Which antidepressant do you think will work best for me?
  • What are the possible side effects of treatment?
  • Do I have to take my antidepressant every day?

This is not intended to result in a diagnosis or a treatment recommendation. It’s meant to help you have a more meaningful discussion with your doctor. No information about you will be collected or stored.

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