Important Safety Information About PRISTIQ
Suicidality and Antidepressant Drugs Antidepressants increased the risk of suicidal thinking and behavior in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy or when the dose is changed should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior such as becoming agitated, irritable, hostile, aggressive, impulsive, or restless. Should these occur, report them to a doctor right away. PRISTIQ is not approved for use in children under 18.

Do not take PRISTIQ if you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ. Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid).

Inside Depression > The Science of Depression > Is depression in our genes?

Sign Up for Inside Depression Updates

Keep learning about depression with this free program that delivers insights and support directly to your inbox—with inspirational extras to help you stay focused on your commitment to feeling better.

Create a Doctor Discussion Guide

Create a list of customized questions about your condition that will help focus your conversation, so you can get the most out of your next doctor’s appointment.

Is depression in our genes?

What our family trees may reveal

Can we inherit conditions like depression from our parents or a distant ancestor? Experts believe in some part, yes. While no one knows for certain exactly what causes depression, the condition is believed to be caused by a combination of genetic and environmental factors, meaning that along with our environment, our genes may very well make us more prone to getting depressed. Of course, this link to our genetic makeup is not limited to depression. Genetics are often linked to other conditions, too.

In fact, nearly all human diseases are believed to be caused by a combination of our personal genetic makeup and the environment we live in. And exactly what potential environmental factors are we talking about? Everything from how well we eat, to how often we’re exposed to infections—even how challenging our childhoods were.

Searching for “Depression Genes”

This has sparked researchers to look for genes that might make a person prone to depression. While there have been a number of studies that appear to pinpoint particular “depression genes,” the results have not been consistent. But some research already suggests that there may be specific genes that indicate a higher susceptibility to developing depression.

What twin studies tell us about depression
Much has been learned about the role genes play in depression through studies with identical and fraternal twins. The findings confirm that depression is a result of both genetic and environmental influences.

Why are twin studies so helpful? Because identical twins share the exact same genetic makeup as one another, and fraternal twins,share at least 50% of their genes. This helps researchers come closer to determining how often depression is caused by influences shared by twins who were raised together, and influences specific to each individual twin.

One study suggests that genetics are responsible for about 39% of a person's depression, while environmental influences are responsible for the other 61%.

What does this all mean? By identifying the genes associated with this widespread condition, researchers are hopeful that they may be able to treat it more effectively. All of which is very encouraging.

PRISTIQ®(desvenlafaxine) is FDA approved to treat depression in adults. Ask your doctor if PRISTIQ may be right for you.

See How PRISTIQ Can Help >

PRISTIQ could be a key in treating your depression symptoms.

Browse Other Articles

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a health care provider. All decisions regarding patient care must be made with a health care provider, considering the unique characteristics of the patient.

The product information provided in this site is intended for residents of the United States. The products discussed herein may have different product labeling in different countries.

Copyright © 2013 Pfizer Inc. All rights reserved. PQP580408-01