Common Side Effects

While the goal of taking PRISTIQ (desvenlafaxine) is to feel better, it’s important to know that everyone responds differently to medication. And when it comes to antidepressants, there are side effects. Many people shy away from antidepressants due to side effects. It can take time to find the right medication for you. You and your doctor can determine if the benefits of treatment outweigh the burden of side effects. Always discuss any side effects you are experiencing with your doctor.

What are the most common side effects of PRISTIQ?

In clinical studies, the most common side effects with PRISTIQ 50 mg were:

  • Nausea
  • Dizziness
  • Sweating
  • Constipation
  • Decreased appetite

These are not all the possible side effects of PRISTIQ 50 mg. For a complete list of side effects, please see Section 6 of the full Prescribing Information.

If you’re concerned about side effects, talk to your doctor.

How often do people stop treatment due to side effects?

It may be helpful to know that in an 8-week clinical study with PRISTIQ, people given PRISTIQ and people given placebo (sugar pill) both reported experiencing side effects. A small percentage (4.1%) of people stopped taking PRISTIQ 50 mg due to side effects; a similar percentage (3.8%) of people given placebo also stopped due to side effects. The most common side effects leading to discontinuation were nausea, dizziness, headache, and vomiting.

Will I gain weight with PRISTIQ?

While people react differently to PRISTIQ, in 8- and 12-week studies there was no clinical difference in weight gain between people who took PRISTIQ 50 mg and those who took placebo (sugar pill).

Will PRISTIQ affect my sex drive?

While people react differently to PRISTIQ, in clinical studies there was a low occurrence of sexual side effects in men and women taking PRISTIQ 50 mg, similar to those who took placebo (sugar pill). Sexual side effects include decreased sex drive, as well as delayed orgasm and ejaculation. Side effects may increase with higher doses.

What if I want to stop taking PRISTIQ?

Stopping an antidepressant medicine, especially suddenly, can cause side effects called discontinuation symptoms. Your health care professional may want to reduce your dose slowly to help avoid these side effects. Some of these side effects may include:

  • Dizziness
  • Nausea
  • Headache
  • Irritability
  • Sleeping problems (insomnia)
  • Anxiety
  • Abnormal dreams
  • Tiredness
  • Sweating
  • Diarrhea

Learn How to Take PRISTIQ