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Side Effects

Doing something nice for someone can make you feel better. It could be as simple as giving someone a smile or kind word, or you could volunteer for a cause you care about.

As with any medication, you may experience side effects while taking PRISTIQ. In clinical studies of the recommended 50 mg dose, the most common side effects with PRISTIQ were:

  • nausea
  • dizziness
  • sweating
  • constipation
  • decreased appetite


In clinical studies of the recommended 50 mg dose of PRISTIQ, there was no clinical difference in weight gain versus placebo (sugar pill) and a low incidence of sexual function disorders in men and women.

In general, side effects occurred most frequently during the first week of treatment in clinical studies. These are not all the possible side effects of PRISTIQ (see Important Safety Information). In clinical studies of the recommended 50 mg dose, the percentage of people who stopped taking PRISTIQ due to side effects was similar to placebo (sugar pill).

Stopping your medication

Stopping an antidepressant medicine, especially suddenly, can cause side effects called discontinuation symptoms. Your health care professional may want to gradually reduce your dose slowly to help avoid these side effects. Some of these side effects may include:

  • dizziness
  • nausea
  • headache
  • irritability
  • sleeping problems
  • anxiety
  • abnormal dreams
  • tiredness
  • sweating
  • diarrhea

Next: Track Your Progress »

Indication

PRISTIQ® is approved for the treatment of major depressive disorder in adults.

Important Safety Information for PRISTIQ

Suicidality and Antidepressant Drugs

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. PRISTIQ is not approved for use in children under 18.

  • People taking MAOIs should not take PRISTIQ.
  • All patients taking antidepressants should be observed closely for signs that their condition is getting worse or that they are becoming suicidal. This is very important when an antidepressant is started or when the dose is changed. Patients should be watched for becoming agitated, irritable, hostile, aggressive, impulsive, or restless. These symptoms should be reported to the patient's health care professional right away.
  • Tell your health care professional about all prescription and over-the-counter medications you are taking or plan to take, including:
    • Medicines to treat migraines or mood disorders, to avoid a potentially life-threatening condition
    • Aspirin, NSAID pain relievers, or blood thinners, because they may increase the risk of bleeding.
  • PRISTIQ may cause or make some conditions worse, so tell your health care professional about all your medical conditions, including if you:
    • Have high blood pressure. Your blood pressure should be controlled before you start taking PRISTIQ and monitored regularly
    • Have heart problems, high cholesterol or triglyceride levels, or a history of stroke
    • Have glaucoma or increased eye pressure
    • Have kidney or liver problems
    • Have or had bleeding problems
    • Have or had depression, suicidal thoughts or behavior
    • Have or had mania, bipolar disorder, or seizures or convulsions
    • Have low sodium levels in your blood
    • Are nursing, pregnant, or plan to become pregnant.
  • Discontinuation symptoms may occur when stopping PRISTIQ, especially when therapy is stopped suddenly. Talk to your health care professional before you stop taking or reduce the dose of PRISTIQ.
  • Until you see how PRISTIQ affects you, be careful driving a car or operating machinery. Avoid drinking alcohol while taking PRISTIQ.
  • Side effects when taking PRISTIQ 50 mg may include nausea, dizziness, sweating, constipation, and decreased appetite.

Please see full Prescribing Information including boxed warning and Medication Guide.



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