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Important Safety Information About PRISTIQ

Suicidality and Antidepressant Drugs Antidepressants increased the risk of suicidal thinking and behavior in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy or when the dose is changed should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior such as becoming agitated, irritable, hostile, aggressive, impulsive, or restless. Should these occur, report them to a doctor right away. PRISTIQ is not approved for use in children under 18.

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How to Take PRISTIQ

One pill, once a day (taken with or without food). With PRISTIQ (desvenlafaxine), the recommended dose proven to relieve depression symptoms is 50 mg. In fact, your doctor may choose to keep you on the 50-mg dose throughout your treatment.

It’s important to tell your doctor about any current or past health problems, as your dose may be affected. Take PRISTIQ exactly as prescribed by your health care professional.

Do not stop taking PRISTIQ without first talking to your health care professional. Stopping an antidepressant medicine, especially suddenly, can cause side effects called discontinuation symptoms. Your health care professional may decrease your dose of PRISTIQ slowly to help reduce these side effects.

How should I take PRISTIQ?

Take PRISTIQ exactly as your health care provider has told you.
Take PRISTIQ at about the same time each day.
PRISTIQ may be taken with or without food.
Swallow PRISTIQ tablets whole with water. Do not divide, crush, chew, or dissolve PRISTIQ tablets because the tablets are time released.
Talk with your health care provider about how long you should use PRISTIQ. Take PRISTIQ for as long as your health care provider tells you to.
Do not stop taking or change the dose of PRISTIQ without talking with your health care provider, even if you feel better.

What if I miss a dose of PRISTIQ?

Take it as soon as you remember
If it is almost time for your next dose, skip the missed dose
Don’t try to “make up” for the missed dose by taking two doses at the same time

What if I take too much?

Do not take more than the prescribed daily amount of PRISTIQ.

If you take more PRISTIQ than the amount prescribed, contact your health care professional immediately.

In case of an overdose, call your health care professional and/or poison control center (1-800-222-1222) or go to the emergency room right away

Can I take PRISTIQ with other medications?

Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid). Allow 7 days after stopping PRISTIQ before starting an MAOI. Taking an MAOI with PRISTIQ can cause serious or even life-threatening side effects.

Before taking PRISTIQ, tell your healthcare professional about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines or psychiatric disorders (including other antidepressants) to avoid serotonin syndrome, a potentially life-threatening condition; aspirin, NSAID pain relievers, or blood thinners because they may increase the risk of bleeding.

Do not take PRISTIQ with other medicines containing venlafaxine or desvenlafaxine.

What should I tell my doctor before taking PRISTIQ?

PRISTIQ may cause or make some conditions worse, so tell your health care professional about all the medical conditions you have or had including:

High blood pressure, which should be controlled before you start taking PRISTIQ and monitored regularly
Heart problems; high cholesterol or triglyceride levels; a history of stroke; glaucoma or increased eye pressure; kidney or liver problems; or low sodium levels in your blood
Bleeding problems
Depression, suicidal thoughts or behavior
Mania, bipolar disorder, or seizures or convulsions
Nursing, pregnancy, or plans to become pregnant. It is not known if PRISTIQ will harm your baby.

Who should not take PRISTIQ?

Do not take PRISTIQ

If you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ.
If you currently take, or have taken within the last 14 days, an MAOI (monoamine oxidase inhibitor) including intravenous methylene blue or the antibiotic linezolid.
It is also important to know that you should not take an MAOI within 7 days of stopping PRISTIQ.

How Your Doctor Can Help

Important Safety Information About PRISTIQ

Suicidality and Antidepressant Drugs

Antidepressants increased the risk of suicidal thinking and behavior in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy or when the dose is changed should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior such as becoming agitated, irritable, hostile, aggressive, impulsive, or restless. Should these occur, report them to a doctor right away. PRISTIQ is not approved for use in children under 18.

Do not take PRISTIQ if you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ. Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid). Allow 7 days after stopping PRISTIQ before starting an MAOI. Taking an MAOI with PRISTIQ can cause serious or even life-threatening side effects.

PRISTIQ may cause or worsen some conditions, so tell your healthcare professional about all the medical conditions you have or had including:

High blood pressure, which should be controlled before starting PRISTIQ and monitored regularly
Heart problems, high cholesterol or triglyceride levels, a history of stroke, glaucoma or increased eye pressure, kidney or liver problems, or low sodium levels in your blood
Bleeding problems
Depression, suicidal thoughts or behavior
Mania, bipolar disorder, or seizures or convulsions
Nursing, pregnancy, or plans to become pregnant

Discontinuation symptoms may occur when stopping or reducing PRISTIQ, so talk to your healthcare professional before stopping or changing your dose.

Until you see how PRISTIQ affects you, be careful driving a car or operating machinery. Avoid drinking alcohol while taking PRISTIQ.

In clinical studies, most common side effects with PRISTIQ 50 mg were nausea, dizziness, sweating, constipation, and decreased appetite.

INDICATION

PRISTIQ^® (desvenlafaxine) is a prescription medication approved for the treatment of major depressive disorder in adults.

Please see full Prescribing Information, including boxed warning, and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

*Terms and Conditions

By using the PRISTIQ Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or state health care programs including any state prescription drug assistance programs and the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
The Card is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other health or pharmacy benefit programs which reimburse you for the entire cost of your prescription drugs.
You will save either $15 or the amount of your co-pay/out-of-pocket cost, whichever is less. Card can only be used for up to 12 prescriptions per year.
You must deduct the value received under this program from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf.
Cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription.
The Card will be accepted only at participating pharmacies.
This Card is not health insurance.
Offer good only in the U.S. and Puerto Rico.
The Card is limited to one person during this offering period and is not transferable.
Pfizer reserves the right to rescind, revoke, or amend the program without notice.
No membership fees.
Card and program expire 6/30/2014.

Program expiration dates are sometimes extended. Confirm dates with your pharmacist.

For more information about the savings card call 1-800-842-6031 or write to:

PRISTIQ Savings Card,
6501 Weston Parkway, Suite 370,
Cary, NC 27513

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a health care provider. All decisions regarding patient care must be made with a health care provider, considering the unique characteristics of the patient.

The product information provided in this site is intended for residents of the United States. The products discussed herein may have different product labeling in different countries.

Important Safety Information | Medication Guide for Patients | Prescribing Information |

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