How to Take PRISTIQ

Most people start with a once-daily 50-mg dose of PRISTIQ (taken with or without food). Your doctor may keep you on your starting dose throughout your treatment. Talk to your doctor about any health conditions you may have, as your dose might be affected.

PRISTIQ should be taken at the same time each day and always swallowed whole, since the tablets are time released.

You should always take PRISTIQ exactly as instructed by your health care professional.

Do not stop taking PRISTIQ without first talking to your health care professional. Stopping an antidepressant medicine, especially suddenly, can cause side effects called discontinuation symptoms. Your health care professional may decrease your dose of PRISTIQ slowly to help reduce these side effects.

How should I take PRISTIQ?
  • Take PRISTIQ exactly as your health care provider has told you.
  • Take PRISTIQ at about the same time each day.
  • PRISTIQ may be taken with or without food.
  • Swallow PRISTIQ tablets whole with water. Do not divide, crush, chew, or dissolve PRISTIQ tablets because the tablets are time released.
  • Talk with your health care provider about how long you should use PRISTIQ. Take PRISTIQ for as long as your health care provider tells you to.
  • Do not stop taking or change the dose of PRISTIQ without talking with your health care provider, even if you feel better.
What if I miss a dose of PRISTIQ?
  • Take it as soon as you remember
  • If it is almost time for your next dose, skip the missed dose
  • Don’t try to “make up” for the missed dose by taking two doses at the same time
What if I take too much?

Do not take more than the prescribed daily amount of PRISTIQ.

If you take more PRISTIQ than the amount prescribed, contact your health care professional immediately.

  • In case of an overdose, call your health care professional and/or poison control center (1-800-222-1222) or go to the emergency room right away
Can I take PRISTIQ with other medications?

Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid). Allow 7 days after stopping PRISTIQ before starting an MAOI. Taking an MAOI with PRISTIQ can cause serious or even life-threatening side effects.

Before taking PRISTIQ, tell your healthcare professional about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines or psychiatric disorders (including other antidepressants) to avoid serotonin syndrome, a potentially life-threatening condition; aspirin, NSAID pain relievers, or blood thinners because they may increase the risk of bleeding.

Do not take PRISTIQ with other medicines containing venlafaxine or desvenlafaxine.

What should I tell my doctor before taking PRISTIQ?

PRISTIQ may cause or make some conditions worse, so tell your health care professional about all the medical conditions you have or had including:

  • High blood pressure, which should be controlled before you start taking PRISTIQ and monitored regularly
  • Heart problems; high cholesterol or triglyceride levels; a history of stroke; glaucoma or increased eye pressure; kidney or liver problems; or low sodium levels in your blood
  • Bleeding problems
  • Depression, suicidal thoughts or behavior
  • Mania, bipolar disorder, or seizures or convulsions
  • Nursing, pregnancy, or plans to become pregnant. It is not known if PRISTIQ will harm your baby.
Who should not take PRISTIQ?

Do not take PRISTIQ

  • If you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ.
  • If you currently take, or have taken within the last 14 days, an MAOI (monoamine oxidase inhibitor) including intravenous methylene blue or the antibiotic linezolid.
  • It is also important to know that you should not take an MAOI within 7 days of stopping PRISTIQ.

How Your Doctor Can Help