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Important Safety Information About PRISTIQ

Suicidality and Antidepressant Drugs Antidepressants increased the risk of suicidal thinking and behavior in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy or when the dose is changed should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior such as becoming agitated, irritable, hostile, aggressive, impulsive, or restless. Should these occur, report them to a doctor right away. PRISTIQ is not approved for use in children under 18.

See More Important Safety Information >

Getting Results

Depression is a serious medical condition that can take so much out of you. But successfully treating depression is a realistic goal. So whether you’re new to treatment or you’ve tried treatments in the past, now is a good time to recommit to feeling better. PRISTIQ (desvenlafaxine) could be a key in treating your depression symptoms.

PRISTIQ is an effective treatment for depression in adults. It’s proven to relieve emotional and physical symptoms of depression as measured by the HAMD-17, a commonly used symptom rating scale. Some of these depression symptoms include:

Emotional Symptoms

Sadness
Irritability
Hopelessness
Feeling guilty
Loss of interest
in activities

Physical Symptoms

Trouble sleeping
Agitation
Fatigue
Weight change
Difficulty
concentrating

In clinical studies, PRISTIQ 50 mg showed significant improvement compared to placebo (sugar pill) on another scale, the Sheehan Disability Scale, which was used to measure the extent to which depression disrupted the following areas:

Work
Social life/leisure activities
Family life/home responsibilities

How quickly does PRISTIQ work?

When taking PRISTIQ, it’s important to give it time to work. Everybody responds differently to treatment. In general, it can take several weeks to feel the full benefit of a prescription antidepressant, although some people will start to feel better sooner.

Don't stop taking PRISTIQ without first talking to your health care professional, even if you don't feel results right away.

How do I take PRISTIQ?

One pill, once a day (taken with or without food).You can start right away at a dose proven to relieve depression symptoms: 50 mg. It's possible that your doctor will keep you at this dose throughout your treatment. It should be taken at the same time each day and always swallowed whole, since the tablets are time released.

You should always take PRISTIQ exactly as instructed by your health care professional. Talk to your doctor about any health conditions you may have, as your dose might be affected.

How can I track my progress on PRISTIQ?

Chart your progress while taking PRISTIQ with My Progress Tracker, an interactive tool that can help you keep track of how you’re feeling over time. Share your progress with your health care professional.

Can I stop taking PRISTIQ when I feel better?

Do not stop taking or change the dose of PRISTIQ without talking with your health care provider, even if you feel better. Stopping an antidepressant medicine suddenly can cause other symptoms.

Side effects may occur when stopping PRISTIQ (discontinuation symptoms), especially when therapy is stopped suddenly. Your health care provider may want to decrease your dose slowly to help avoid side effects. Some of these side effects may include:

Dizziness
Anxiety
Nausea
Abnormal dreams
Headache

Tiredness
Irritability
Sweating
Sleeping problems (insomnia)
Diarrhea

View Common Side Effects

Important Safety Information About PRISTIQ

Suicidality and Antidepressant Drugs

Antidepressants increased the risk of suicidal thinking and behavior in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy or when the dose is changed should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior such as becoming agitated, irritable, hostile, aggressive, impulsive, or restless. Should these occur, report them to a doctor right away. PRISTIQ is not approved for use in children under 18.

Do not take PRISTIQ if you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ. Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid). Allow 7 days after stopping PRISTIQ before starting an MAOI. Taking an MAOI with PRISTIQ can cause serious or even life-threatening side effects.

Before taking PRISTIQ, tell your healthcare professional about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines or psychiatric disorders (including other antidepressants) to avoid serotonin syndrome, a potentially life-threatening condition; aspirin, NSAID pain relievers, or blood thinners because they may increase the risk of bleeding.

PRISTIQ may cause or worsen some conditions, so tell your healthcare professional about all the medical conditions you have or had including:

High blood pressure, which should be controlled before starting PRISTIQ and monitored regularly
Heart problems, high cholesterol or triglyceride levels, a history of stroke, glaucoma or increased eye pressure, kidney or liver problems, or low sodium levels in your blood
Bleeding problems
Depression, suicidal thoughts or behavior
Mania, bipolar disorder, or seizures or convulsions
Nursing, pregnancy, or plans to become pregnant

Discontinuation symptoms may occur when stopping or reducing PRISTIQ, so talk to your healthcare professional before stopping or changing your dose.

Until you see how PRISTIQ affects you, be careful driving a car or operating machinery. Avoid drinking alcohol while taking PRISTIQ.

In clinical studies, most common side effects with PRISTIQ 50 mg were nausea, dizziness, sweating, constipation, and decreased appetite.

INDICATION

PRISTIQ^® (desvenlafaxine) is a prescription medication approved for the treatment of major depressive disorder in adults.

Please see full Prescribing Information, including boxed warning, and Medication Guide.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

*Terms and Conditions

By using the PRISTIQ Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or state health care programs including any state prescription drug assistance programs and the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
The Card is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other health or pharmacy benefit programs which reimburse you for the entire cost of your prescription drugs.
You will save either $15 or the amount of your co-pay/out-of-pocket cost, whichever is less. Card can only be used for up to 12 prescriptions per year.
You must deduct the value received under this program from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf.
Cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription.
The Card will be accepted only at participating pharmacies.
This Card is not health insurance.
Offer good only in the U.S. and Puerto Rico.
The Card is limited to one person during this offering period and is not transferable.
Pfizer reserves the right to rescind, revoke, or amend the program without notice.
No membership fees.
Card and program expire 6/30/2014.

Program expiration dates are sometimes extended. Confirm dates with your pharmacist.

For more information about the savings card call 1-800-842-6031 or write to:

PRISTIQ Savings Card,
6501 Weston Parkway, Suite 370,
Cary, NC 27513

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a health care provider. All decisions regarding patient care must be made with a health care provider, considering the unique characteristics of the patient.

The product information provided in this site is intended for residents of the United States. The products discussed herein may have different product labeling in different countries.

Important Safety Information | Medication Guide for Patients | Prescribing Information |

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