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PRISTIQ supports
you throughout your
treatment with My
Progress Tracker. This
downloadable interactive tool lets you easily chart your progress over time, and share your results with your doctor. See demo

Considering PRISTIQ? Request a free information kit. Already taking PRISTIQ? Join A New Day®, an educational program designed to help support you during treatment.

What to Expect

Keep moving—it may help you feel better physically and can help improve your self-esteem. You don’t need special equipment or a gym membership. A walk outdoors can do the trick.

What results can I expect when I take PRISTIQ?

PRISTIQ is proven to relieve a broad range of depression symptoms:

Emotional Symptoms

  • constant sadness
  • irritability
  • hopelessness
  • feeling worthless or guilty for no reason
  • loss of interest in favorite activities

Physical Symptoms

  • trouble sleeping
  • low energy or fatigue
  • significant weight change
  • difficulty concentrating

In clinical studies, PRISTIQ 50 mg showed significant improvement compared to placebo (sugar pill) on the Sheehan Disability Scale. In these studies, this scale was used to measure the extent to which depression disrupted:

  • work
  • social life/leisure activities
  • family life/home responsibilities

You may experience side effects when taking PRISTIQ. At the recommended 50 mg dose, side effects of PRISTIQ may include nausea, dizziness, sweating, constipation, and decreased appetite. In general, side effects occurred most frequently during the first week of treatment in clinical studies. This is not a complete list of side effects (see Important Safety Information).

How quickly does PRISTIQ work?

The starting dose of PRISTIQ—50 mg—is also the recommended dose for the relief of symptoms of depression. This means that you may not have to increase your dose over time. The dose you start on might be the dose your doctor thinks is right for you. It is possible that you will remain at this dose throughout your treatment.

When taking PRISTIQ, it’s important to give it time to work. Everybody responds differently to treatment. In general, it can take several weeks to feel the full benefit of a prescription antidepressant, although some people will start to feel better sooner.

Don't stop taking PRISTIQ without first talking to your health care professional, even if you don't feel results right away.

Can I stop taking PRISTIQ when I feel better?

Do not stop taking or change the dose of PRISTIQ without talking with your health care provider, even if you feel better. Stopping an antidepressant medicine suddenly can cause other symptoms

Side effects may occur when stopping PRISTIQ (discontinuation symptoms), especially when therapy is stopped suddenly. Your health care provider may want to decrease your dose slowly to help avoid side effects. Some of these side effects may include:

  • dizziness
  • anxiety
  • nausea
  • abnormal dreams
  • headache
  • tiredness
  • irritability
  • sweating
  • sleeping problems (insomnia)
  • diarrhea

Next: Common Questions »

Indication

PRISTIQ® is approved for the treatment of major depressive disorder in adults.

Important Safety Information for PRISTIQ

Suicidality and Antidepressant Drugs

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. PRISTIQ is not approved for use in children under 18.

  • People taking MAOIs should not take PRISTIQ.
  • All patients taking antidepressants should be observed closely for signs that their condition is getting worse or that they are becoming suicidal. This is very important when an antidepressant is started or when the dose is changed. Patients should be watched for becoming agitated, irritable, hostile, aggressive, impulsive, or restless. These symptoms should be reported to the patient's health care professional right away.
  • Tell your health care professional about all prescription and over-the-counter medications you are taking or plan to take, including:
    • Medicines to treat migraines or mood disorders, to avoid a potentially life-threatening condition
    • Aspirin, NSAID pain relievers, or blood thinners, because they may increase the risk of bleeding.
  • PRISTIQ may cause or make some conditions worse, so tell your health care professional about all your medical conditions, including if you:
    • Have high blood pressure. Your blood pressure should be controlled before you start taking PRISTIQ and monitored regularly
    • Have heart problems, high cholesterol or triglyceride levels, or a history of stroke
    • Have glaucoma or increased eye pressure
    • Have kidney or liver problems
    • Have or had bleeding problems
    • Have or had depression, suicidal thoughts or behavior
    • Have or had mania, bipolar disorder, or seizures or convulsions
    • Have low sodium levels in your blood
    • Are nursing, pregnant, or plan to become pregnant.
  • Discontinuation symptoms may occur when stopping PRISTIQ, especially when therapy is stopped suddenly. Talk to your health care professional before you stop taking or reduce the dose of PRISTIQ.
  • Until you see how PRISTIQ affects you, be careful driving a car or operating machinery. Avoid drinking alcohol while taking PRISTIQ.
  • Side effects when taking PRISTIQ 50 mg may include nausea, dizziness, sweating, constipation, and decreased appetite.

Please see full Prescribing Information including boxed warning and Medication Guide.



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